MEMBRANE RECEPTORS and their role in cancer and fetal development

Every new life and human being arises from cellular and biochemical processes that take place in their parents. Many processes have to succeed long before the actual fertilization situation before we can even start talking about a fetus or a growing human being.

At the end of a life, however, cancer may be the ultimate destination and terminate the existence of a human being.

We aim to provide knowledge about the role of different membrane receptors in the development and progression of certain cancers and in fetal development. There are many overlapping mechanisms.

Our particular interest is how cancer cells interact and cooperate with surrounding cells in the tumor microenvironment and how the cancer cells are affected by this. In particular, we focus on the immune cells that infiltrate the tumors.

Today, progress has been made regarding treatment for patients with late stages of cancer. Many of these patients benefit from immunotherapy with check point inhibitors. And precisely for this reason, more knowledge is needed on how the cancer cells are affected by the surrounding immune cells and how the cancer cells develop and change during treatment with immunotherapy.

At the same time, there are still many patients with advanced stages of cancer who do not benefit from immunotherapy. More knowledge is needed as to why these patients are non-responders and how they may be treated with novel drugs in order to become responders of immunotherapy. All of this is also our focus area.

Our specific disciplines are especially melanoma cancer and breast cancer.


February 2015
Research article published in:
Pigment Cell & Melanoma Research

Melanoma tumors frequently acquire LRP2/megalin expression, which modulates melanoma cell proliferation and survival rates.

December 2016:
Research article published in:
Journal of Histochemistry and Cytochemistry
Megalin is predominantly observed in vesicular structures in first and third trimester cytotrophoblasts of the human placenta.

December 2018:
Mette Madsen coauthor of paper published in:
Nature Communications
Structural assembly of the megadalton-sized receptor for intestinal vitamin B12 uptake and kidney protein reabsorption.