Publications


Publications list, Mette Madsen
(previously: Mette Kristiansen)

1) Søren K. Moestrup, Renata Kozyraki, Mette Kristiansen, James H. Kaysen, Hanne Holm Rasmussen, Didier Brault, Francoise Pontillon, Fatime O. Goda, Erik I. Christensen, Timothy G. Hammond and Pierre J. Verroust, The intrinsic factor-vitamin B12 receptor and target of teratogenic antibodies is a megalin binding peripheral membrane protein with homology to developmental proteins (1998), J. Biol. Chem. 273, 5235-5242.

2) Renata Kozyraki*, Mette Kristiansen*, Asli Silahtaroglu, Claus Hansen, Christian Jacobsen, Niels Tommerup, Pierre J. Verroust and Søren K. Moestrup, The human intrinsic factor-vitamin B12 receptor, cubilin: molecular characterization and chromosomal mapping of the gene to 10p within the autosomal recessive megaloblastic anemia (MGA1) region (1998), Blood 91, 3593-3600 (*shared first authorship).

3) Renata Kozyraki, John Fyfe, Mette Kristiansen, Christian Gerdes, Christian Jacobsen, Shiying Cui, Erik I. Christensen, Maria Aminoff, Albert de la Chapelle, Ralf Krahe, Pierre J. Verroust and Søren K. Moestrup, The intrinsic factor-vitamin B12 receptor, cubilin, is a high-affinity apolipoprotein A-I receptor facilitating endocytosis of high-density lipoprotein (1999), Nature Medicine 5, 656-661.

4) Mette Kristiansen, Renata Kozyraki, Christian Jacobsen, Ebba Nexø, Pierre J. Verroust and Søren K. Moestrup, Molecular dissection of the intrinsic factor-vitamin B12 receptor, cubilin, discloses regions important for membrane association and ligand binding (1999), J. Biol. Chem. 274, 20540-20544.

5) Mette Kristiansen, Maria Aminoff, Christian Jacobsen, Albert de la Chapelle, Ralf Krahe, Pierre J. Verroust and Søren K. Moestrup, Cubilin P1297L mutation associated with hereditary megaloblastic anemia 1 (MGA1) causes impaired recognition of intrinsic factor-vitamin B12 by cubilin (2000), Blood 96, 405-409 (selected as Plenary paper).

6) Mette Kristiansen*, Jonas H. Graversen*, Christian Jacobsen, Ole Sonne, Hans-Jürgen Hoffman, S.K. Alex Law and Søren K. Moestrup, Identification of the haemoglobin scavenger receptor (2001), Nature 409, 198-201 (*shared first authorship).

7) Mette Madsen, Den molekylære baggrund for medfødt vitamin B12-mangel (Imerslund-Gräsbecks syndrom) (2001), Klinisk Kjemi i Norden 4, 27-29.

8) Mette Madsen, Jonas H. Graversen and Søren K. Moestrup, Haptoglobin and CD163: captor and receptor gating hemoglobin to macrophage lysosomes (2001), Redox Report 6, 386-8.

9) Jonas Heilskov Graversen, Mette Madsen, Søren K. Moestrup, CD163: a signal receptor scavenging haptoglobin-hemoglobin complexes from plasma (2002), Int. J. Biochem. Cell Biol. 34, 309-314.

10) Ivo R. Horn, Marianne J. Nielsen, Mette Madsen, Christian Jacobsen, Jonas H. Graversen and Søren K. Moestrup, Generation of a haptoglobin-hemoglobin complex-specific Fab antibody blocking the binding of the complex to CD163 (2003), Eur. J. Haematol. 71, 289-93.

11) John C. Fyfe*, Mette Madsen*, Peter Højrup, Erik I. Christensen, Stephan M. Tanner, Albert de la Chapelle, Qianchuan He and Søren K. Moestrup, The functional cobalamin (vitamin B12)-intrinsic factor receptor is a novel complex of cubilin and amnionless (2004), Blood 103, 1573-9 (*shared first authorship).

12) Mette Madsen, Holger J. Møller, Marianne Jensby Nielsen, Christian Jacobsen, Jonas H. Graversen, Timo van den Berg and Søren K. Moestrup, Molecular characterization of the haptoglobin-hemoglobin receptor CD163: Ligand binding properties of the scavenger receptor cysteine-rich domain region (2004), J. Biol. Chem., 279, 51561-7.

13) Gwénaëlle Coudroy, Jakub Gburek, Renata Kozyraki, Mette Madsen, Germain Trugnan, Søren K. Moestrup, Pierre J. Verroust and Michèle Maurice, Contribution of cubilin and amnionless to processing and membrane targeting of cubilin-amnionless complex (2005), J. Am. Soc. Nephrol., 16, 2330-7.

14) Qianchuan He, Mette Madsen, Adam Kilkenney, Brittany Gregory, Erik I. Christensen, Henrik Vorum, Peter Højrup, Alejandro A. Schäffer, Ewen F. Kirkness, Stephan M. Tanner, Albert de la Chapelle, Urs Giger, Søren K. Moestrup and John C. Fyfe, Amnionless function is required for cubilin brush-border expression and intrinsic factor-cobalamin (vitamin B12) absorption in vivo (2005), Blood, 106, 1447-53.

15) Marianne Jensby Nielsen, Mette Madsen, Holger J. Møller and Søren K. Moestrup, The macrophage scavenger receptor CD163: endocytic properties of cytoplasmic tail variants (2006), J. Leukoc. Biol., 79, 837-845.

16) Holger Jon Møller, Marianne Jensby Nielsen, Maciej Bogdan Maniecki, Mette Madsen, and Søren Kragh Moestrup, Soluble macrophage-derived CD163: A homogenous ectodomain protein with a dissociable haptoglobin-hemoglobin binding (2010), Immunobiology, 215, 406-12.

17) Gitte Albinus Pedersen*, Souvik Chakraborty*, Amie L. Steinhauser, Linton M. Traub, Mette Madsen, AMN directs endocytosis of the intrinsic factor-vitamin B12 receptor cubam by engaging ARH or Dab2 (2010), Traffic, 11, 706-720 (*shared first authorship).

18) Christian Brix Folsted Andersen*, Mette Madsen*, Tina Storm, Søren K. Moestrup, and Gregers R. Andersen, Structural Basis for Receptor Recognition of Vitamin B12-Intrinsic Factor Complexes (2010), Nature, 464, 445-8 (*shared first authorship). http://mb.au.dk/en/single-news/artikel/danish-breakthrough-in-vitamin-research/

19) Anthony R. Vortherms, Anna Kahkoska, Amy E. Rabideau, Jon Zubieta, Louise Lund Andersen, Mette Madsen, and Robert P. Doyle, A water soluble vitamin B(12)-Re(i) fluorescent conjugate for cell uptake screens: use in the confirmation of cubilin in the lung cancer line A549 (2011), Chem Commun (Camb), 47, 9792-4.

20) Olivier Cases, Aitana Perea-Gomez, Diego P. Aguiar, Anders Nykjaer, Sabine Amsellem, Jacqueline Chandellier, Muriel Umbhauer, Silvia Cereghini, Mette Madsen, Jérôme Collignon, Pierre Verroust, Jean-François Riou, Sophie E. Creuzet, and Renata Kozyraki, Cubilin, a high affinity receptor for fibroblast growth factor 8, is required for cell survival in the developing vertebrate head (2013), J. Biol. Chem., 288, 16655-70.

21) Tina Storm, Christina Zeitz, Olivier Cases, Sabine Amsellem, Pierre J. Verroust, Mette Madsen, Jean-Francois Benoist, Sandrine Passemard, Sphie Lebon, Iben Møller Jønsson, Francesco Emma, Heidi Holdsø, Jens Michael Hertz, Rikke Nielsen, Erik I. Christensen, and Renata Kozyraki, Detailed investigations of proximal tubular function in Imerslund-Grasbeck syndrome (2013), BMC Med Genet, 14, doi:10.1186/1471-2350-14-111.


22) Louise Lund Jensen, Rikke K. Andersen, Henrik Hager, and Mette Madsen, Lack of megalin expression in adult human terminal ileum suggests megalin-independent cubilin/amnionless activity during vitamin B12 absorption (2014), Physiological Reports, pii: e12086, doi: 10.14814/phy2.12086.   


23) Rikke Katrine Andersen, Katrine Hammer, Henrik Hager, Julie Nelly Christensen, Maja Ludvigsen, Bent
Honoré, Mai-Britt Holden Thomsen, and Mette Madsen, Melanoma tumors frequently acquire LRP2/megalin expression, which modulates melanoma cell proliferation and survival rates, Pigment Cell & Melanoma Research, 2015 Jan doi: 10.1111/pcmr.12352.

24) Tina Storm, Erik I. Christensen, Julie Nelly Christensen, Tine Kjaergaard, Agnete Larsen, Bent Honoré, and Mette MadsenMegalin is predominantly observed in vesicular structures in first and third trimester cytotrophoblasts of the human placenta, Journal of Histochemistry and Cytochemistry, 2016, 64 (12), 769-784.